I don't know why the OP disables it, but chrome used to block my desktop from sleeping because 'WebRTC has active peer connections'.

I don't appreciate web pages or applications or whatever blocking my system from sleeping so i just turn off WebRTC since then.

Edit: I was not doing anything related to video, audio, p2p or anything else implying long running connections explicitly. Some "experts" were doing it behind my back on their pages. Don't know and don't care why.

Perhaps holepunching of a certain offsite JS-based app in your browser is the problem there. InfoSec know this all too well.

Things like JS-based portscanning, file-less malware in JS datastore, …