Actually I take it back, Acrobat is probably #1
Heck, I am frustrated that Canva didn’t have a layers panel, and now that they do, that it doesn’t behave the way I expect and I can’t pull it up easily… or that Canva makes it impossible to ensure assets match when searching for a matching sequence or set of templates. Or all the ways I can’t just do the thing I’m thinking of by right clicking or modifying layers or something. Canva itself is an exercise in frustration for power users. Affinity ain’t perfect either. Great matchup, really.
Text rendering algorithms are quite known quantity and lifted from LaTeX. Indesign has paragraph (multi-line) composer which in latex equivalent is microtype package. Affinity doesn't have that but paragraph composer is not really used that much in professional setting because when you do final manual fixes/adjustment of typography then with paragraph composer your changes could affect previous changes in paragraph (so people go by line by line). Paradoxically paragraph composer is pretty good for quickly getting OK enough results especially in more budget/non-pro setting.
Other than that i don't think the typography output (for print) is different I've seen some tests and it seems kinda exactly the same. Affinity might render type on screen a bit differently but the output is solid. I was more afraid of the quality of .pdf itself but even highend offset printers didn't see a difference/complained.
After Effects simplicity compared to the hellscape that can be node-based VG work. I mean, the programmer in me loves nodes, I even used MaxMSP frequently… and Origami. But the simplicity of After Effects is really nice and it has like every plugin in existence.
Don’t get me wrong, I use DaVinci with the quick editor and have considered buying other gear to make it work better, but… it’s really kinda a jack-of-all-trades, master-of-color-grading app. There’s a lot still to wish for.