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Comment by __MatrixMan__ | Hacker News Reader

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__MatrixMan__·

> Each package shipped with 1,000,000 micrograms

Woah there buddy. 100 droplets at 1,000 μg each = 100,000 μg.

I was a little surprised to learn that they didn't just dilute it a bit more and soak the entire sheet.

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And on that note, as a non-user, surprising that the standard tab is 1,000 μg and one is expected to just know that you should divide it into quarters just to get a mere "above average dose". Or into tenths or twentieths of a tab to get an average or below average dose, respectively. It seems to invite a white-knuckle ride.

Those numbers remind me of https://notsoprofound.com/the-unforeseen-lsd-overdose-of-197...

If you soak the entire sheet, I don't think you can be certain how much active product a single blotter absorbed

But with the make-100-droplets technique, how can you be sure that each droplet contains the same amount? You're still relying on diffusion of solutes to achieve some degree of uniformity across several fixed volumes.

Diffusion in liquid is relatively consistent. When paper is soaked and allowed to dry, it can produce uneven concentrations as regions evaporate at different rates, and solutes move along with the flow of solvent. A good example of this is water color painting: if you mix paint into water and then apply it to the paper, the resulting patterns may be less uniform than when applied.

I see, thanks. I guess drying is essentially crystal regrowth, and the thing about growing crystals is that the material concentrates around the nucleation sites and spoils the nice even distribution that you get from being in solution.

Seems like one can expect a hit to be a more precise dose than a half-hit, presuming it's still done that way.

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