No issues, even with AAA games like Cyberpunk 2077. Anti-cheat is a thing they're working on too, but ultimately it'll require kernel modules and I'm not cool with that, but more in the "not gonna play those games" sense.
As for other things, like various hyperspecific professional software people are locked into, I've got nothing but sympathy for those folks. It's a rough situation and it's not their fault. It'll take people who care about those domains doing software projects to help open up those areas more. I will note that I know people producing content who have been going over to FOSS video editors and the like lately, and I can't say for sure whether this is the platforms getting worse or the FOSS getting better, but I think either way alternatives exert positive pressure on the ecosystem as a whole. I do think it would help a lot if professionals in many areas would be a bit more willing to at least try alternatives, as the reaction to projects aiming to give them choices tends to be derision and dismissal. Like, okay some stuff isn't there yet, but I think it would benefit you if it was, even if you personally don't use it
If there's anything people should have learned from the last few decades, it's that no company will ever love or care about you, and a company that deserves your trust is rare to the point of near-extinction in this environment. And yet people actively bemoaning how these companies are shaking them down will at the same time act and speak against their own interests out of brand loyalty. Perhaps it is because so many have come to define themselves by their choices as consumers. It's hard not to see identity itself as a sort of scam in this kind of environment