Cancer under age 50 increased 80% from 1990 to 2019
bmjoncology.bmj.com
bmjoncology.bmj.com
I get it PFAs might not cause cancer but we’re pushing things to some pretty crazy extreme when it comes to pollution. Microplastics in the clouds ?
I really hope these things aren’t related because it’s going to fucking suck if they are. Can’t just put microplastics away.
I’m personally in the camp that thinks we should just be doing everything we can to minimise all types of pollution because we just cannot really predict what the effects will be. Even if we think something is benign.
I might be an extremist but I’m even worried about tyre dust. And even those blue plastic tarps people love to let rot in the sun and dissolve everywhere.
What we’re doing isn’t good, I just think we struggle to admit to ourselves because it’s quite horrific.
[1] https://phys.org/news/2022-08-rainwater-unsafe-due-chemicals...
What worries me is this is always going to be about a quick buck vs long term risk. We do not have the collective wisdom to stop.
How many more decades do we need?
Given we are seeing plunging birth rates and species unprecedented rate (a dozen to hundreds of species a day), I'd say shifting to a "you have to prove it's not harmful" is a good policy.
Besides, lots of excellent drugs are used in a trigger-happy way. Take for instance antibiotics, which are one of the greatest achievements of modern science. Lots of children are prescribed antibiotics for mild infections, i.e. when they don't need them, ignoring side-effects. Thankfully, doctors are starting to be a bit more cautious.
This is one of the reasons autoimmunity has skyrocketed during the last 50 years, and quite a few friendly commensal bacteria are nearly extinct. Persistent gut inflammation, below what is considered autoimmunity, is responsible for lots of colon cancer cases in adults. It is all tied.
Could you imagine what rivers in China and India look like ?
I do agree we have improved in some areas for sure. But we don’t get clouds contaminated with plastic for no reason.
When running industries, there is unfortunately no free lunch -- someone's paying the consequences. If not you, someone upstream who made the raw materials or any priors.
Basically, don’t buy a home in a area where there were historically military facilities, especially Air Force, or defense contractors without careful review.
We don't know yet just how much harm microplastics are causing us, but the fact that they are everywhere (including in your blood and organs) isn't helping. I don't think there's anything hysterical about all of earth's water being unsafe to drink unless it's filtered. (https://www.su.se/english/news/it-s-raining-pfas-even-in-ant...). The world has never been poisoned at this scale before. Your body is already polluted, and our children's bodies will be polluted from the moment they are born.
Just consider this study, which is simply bad reporting. Check out some of the other comments in this thread, but all of these numbers can simply be explained by the growth in the global population during the study period. Actual per-capita cancer deaths among young people are way down during this timeframe.
We might’ve seen a decline in cancer rates even with more people if we didn’t pollute so much.
Imagine living in a less polluted world with the medicine we have now ? Wouldn’t that be fantastic?
You're right though that we ought to be careful and try to reduce bad stuff. I suspect that will be key to increasing our life expectancy even further.
Ted Kaczynski would like to ask about the average amount of happy years lived.
> with notable variances in mortality and DALYs between areas, countries, sex and cancer types. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.
and...
> Dietary risk factors (diet high in red meat, low in fruits, high in sodium and low in milk, etc), alcohol consumption and tobacco use are the main risk factors underlying early-onset cancers.
seems to indicate that the authors of this article were not pointing the finger at environmental causes.
> Zhao et al report 79% increase in actual number of cases from 1990 to 2019, but this figure can be misleading, as it does not take account of population growth. The authors therefore also report estimated annual percent change (EAPC) of the incidence rates of various cancers. However, it is unfortunate that the press has largely focused on the overall number rather than the per capita risk of cancer, giving the impression that we are facing an epidemic of cancer in young individuals. https://bmjoncology.bmj.com/content/2/1/e000049.responses
The headline figure of 79% does not account at all for population increase. This is bad science (communication).
> In 2019, the incidence number of early-onset cancer was 3.26 million, a 79.1% increase from 1990 (figure 1A,B).
Incidence number simply counts cancers. Of course there are more cancers given world population increase. This should never be in a study headline.
> However, focusing on absolute case numbers does not take into account that the global population in the age group 15-49 increased by 45% and in the age group 40-49 (where most incident cases have occurred) by 86% during the study period (see Table S2). Both, age specific and age standardized rates show no increase in incidence in incidence and mortality for the period 1995 to 2020 (Figure 5). Age standardized mortality declined substantially during the study period.
I also think there are many forces at play. We've started:
- consuming more packaged goods
- selling unhealthy things as healthy
- doing less physical labor
- having more mental health problems at a young age
I feel a study like this does nothing to tell us what the cause is, just noting the sensationalized effect.
As they start developing, they are able to import things with high levels of preservatives etc.
You seem to be mixing undeveloped (Port au Prince, Khartoum, Dhaka, etc) up with "tribal". They still have access to pesticides, heavy metals, low-quality/toxic feeds, gasoline, etc; in addition to having generally very lax/non-existent regulations.
If you spend any time in India, for example? Holy moly.
A lot of obesity in developing economies comes from people who have experienced food scarcity overcompensating and overfeeding themselves and their children.
This is true and easily observable everywhere, even in advertising. I'm in the Philippines at the moment, and there's a trope in Filipino television advertising that includes the "cute, chubby/fat kid." Having a chubby kid signifies to other Filipinos that you are middle class and have enough money and resources to overfeed your child.
That being said, to give an example, an excess of lard is linked to increased obesity in Mexico.
Which befuddles my industry joke of TLA (three letter acronyms) since it is pronounced as T.L.A. Not “tella”
This is 100% false that most of rural America still burns trash.
I grew up on a farm, we burnt trash and stopped before I barely remember seeing any fires. Not because we are environmentalist, but because we were told to stop just like everyone else in the state.
1) Fewer people in developing countries are dying from other things than they were 30 years ago, for example malnutrition and maternal or infant mortality.
2) Better diagnostics and screening. Screening is a big deal, in a sufficiently immature medical system you'll have people who die of cancer that never even get diagnosed. Start doing better screening and you will find and treat these cases earlier.
The fact that one of the biggest increases was in prostate cancer supports this idea (at least to my layman's eye). Prostate cancer tends to remain benign for a long time so you won't catch it without screening.
If you look at the right-hand column you will notice, compared to the West, there's barely any cancer in Africa! (Incidence rate is very low) Of course that isn't because no one gets cancer in Africa, it's because much of the population has limited access to screening/diagnoses.
I don't think we need to leap to the conclusion that microplastics are causing cancer to skyrocket.
In the developed world it is almost all good news. Incidence rates are flat to down over the last 30 years. Death rates are flat to dramatically down due to improved treatment.
Here is a direct link https://bmjoncology.bmj.com/content/bmjonc/2/1/e000049/F3.la...
This diagram: https://bmjoncology.bmj.com/content/bmjonc/2/1/e000049/F1.la...
Shows about 800K deaths in 1990 vs 1M deaths in 2019. That's 25% at best--or less when adjusted for population growth.
And the proportions stayed roughly the same.
That would strongly suggest that the increase is mostly detection.
However, I think that is about to change. Rapidly.
I see biomed as broken into 3 eras much like any technical field--alchemy, science, and then engineering.
The invention of PCR in 1984 is when biomed changed from being alchemy to being an actual science. The application of mRNA heralds the start of the era where biomed is switching to having progress from engineering rather than just science and some serendipitous luck.
And once something switches to being engineering, it can be accelerated by education and money.
I believe you're correct. But I also believe such a shift will likely come witb unintended consequences. What might those be?
Note: nuclear fusion is similar. That is, loads of cheap clean energy is certainly a victory but there are also massive geopolitical and financial systems unintended consequences. It's not all rainbows and unicorns
Introduction: "Currently, it was reported that the promotion of cancer screening strategies and the exposure to risk factors in early life or young adulthood may increase incidence of early-onset cancer... Furthermore, changes in diet, lifestyle and environment since the turn of the 20th century, resulting in increased rates of obesity, physical inactivity, westernised diets and environmental pollution, may have affected the incidence of early-onset cancer. Additionally, alcohol, smoking and detrimental pregnancy exposures may have also affected the incidence of early-onset cancer"
Conclusion: "Our study showed that the global morbidity of early-onset cancer increased from 1990 to 2019, while mortality and DALYs slightly decreased."
Note: I personally believe it probably has but such an opinion is not science.
Refs: https://informahealthcare.com/doi/abs/10.3109/09553001003734... https://www.sciencedirect.com/science/article/abs/pii/S00062...
It could be other things that effect hormones.
For example the pill, that is taken by so many people, or just people over consuming sugar, and getting fatter.
They used the rate by 100K in most other figures but the one the title refers to doesn't.
People are way too lax about what they put into their body, and trusting. Taking pills for things that are often lifestyle related.
Trying to mask the symptoms with pharmaceuticals and not trying to fix the cause...like obesity, and excessive alcohol.
This is one of the reasons I did not take the covid jab. I was worried it would give me cancer. I was okay with getting fired.
I wouldn't get a tattoo either for same reason.
A “toxin” is a naturally occuring poison, such as snake venom. The word you're looking for is the umbrella term “toxicant”.
See: https://en.wikipedia.org/wiki/Toxicant
But, pendantry aside, pretty sure a lot of those plastic toys, especially the sort of rubbery squishy ones, are probably loaded with pthalates and other exotic and interesting things.
It's like the people dying on that pedantry hill over "literally" being now used in slang to just mean "a lot / really significantly" rather than "how something appears in literature". I'm sure there were people equally complaining about the death of the English subjunctive verb [1].
Anyway, “Toxicant” is a perfectly cromulent word.
Gas stoves however.. they spike voc and co2 around the house when used.
The “western” medicine still neglects TCM and its learnings, primarily focusing on doctrine and enforced lessons of medicine (if we may call it so), but more appropriately post-medicine which is or can be more or less effective after the disease has developed to a visible to sensory state.
It will take some time (or more given the current condition in which the westerns are more concerned in shipping and producing the weapons than raising the vibration of their planetary bodies) to understand that post-condition-medicione is negligible against preventive medicine and if they will want to preserve health in their human bodies, something radical will need to be changed (which will be a challenge for their established trajectory of thought but the appropriate holistic approach to health and medicine of the future).
Alternative medicine that works becomes medicine.
I'm not against western medicine, I'm just missing more focus on causes of illnes and explanations, not just solving consequences.
Moral: These are very loaded figures. Enough to make small naive children make protests and the world to notice. The numbers are very diluted based on agenda. Cancer patients might have increased, seems very plausible. But did the study account population increase or simply number of people reporting ? I don't think so. We all want to make world a better place but take these numbers with a grain of salt.
It seems like you want to say "be skeptical about numbers.". Fine. But what does that have to do with the course?
As it stands, the population has not grown 80% in the timespan given so even if they didn't control for population - which would be the most elementary mistake ever and no one would get published having made it - it still doesn't account for the effect size.
Reflexive scepticism, without any effort to verify, isn't any more useful than reflexive belief.