>Likewise, a prospective study among patients with stage III CRC found that consuming more than 4 cups/d of coffee was associated with improved disease-free survival compared with non-coffee drinkers.
Again, in these studies there seems to be no standardization of what defines the size of a cup of cofee.
In Italy, according to my Bialetti Mokka Pot, a "cup" means a coffee the size of a cumshot, but is intense and concentrated AF, while in the Land of the Free™, a coffee you see people walk with in their hands can be the size of a big-gulp but is just watered down plunk with milk and sugar.
Then comes the other questions. What is the extraction in each cup? What is the caffeine content? Won't the caffeine from 4 cups/day mess with your sleep enough to offset the benefits?