Comment by grumpy-de-sre | Hacker News Reader

Comment by grumpy-de-sre | Hacker News Reader

Now that's some serendipitous reading.

I've been on the hunt for possible mechanisms (for further study) as to why last year after trying an SSRI (escitalopram), to treat an anxiety disorder co-morbid to my ASD, that I ended up in the hospital in a hypertensive crisis. Was an all around terrible experience and I hope one day I can figure out WTF happened to me.

Interestingly the BP rise seemed to be mostly diastolic driven and I had crazy excessive urination which made me think about ADH/aldosterone/etc. Seeing ADH is potentially linked to ASD definitely catches my attention! Some of the alternative theories are, I am a MAO-A knockout (unlikely because of lack of intellectual disability), or possess a hyperfunctional SERT (also linked to ASD).

Really excited for the results of the whole genome sequencing I ordered to arrive.

ive been doing my own research for similar reasons (zoloft in my case), although i fortunately did not end up in a hospital. my girlfriend works with autistic children and swears i have ASD but I havent gotten around to being officially diagnosed, nor am i fully convinced of her claim. if you dont mind sharing, what genome sequencing service did you use? granted i havent looked too far but a lot of services i saw were kinda sketchy. hope u find the answers u seek :)

Oh the popular WGS services are a borderline scam. I fell for their BS unfortunately so are out a few hundred euros. I don't expect to see results for 12 months or more (if ever).

In the end I found a local company that does WGS sequencing and they are a lot more reasonable to deal with, maybe 1.5-2x the price. So perhaps look for smaller providers, they are all just reselling time on the same Illumina machines.

In your case, just confirming, your blood pressure is otherwise normal and you experienced an episode of severe hypertension after starting Sertraline (zoloft)? No other contraindicated medications? No indications of a bipolar/mania or something of that nature? I've talked to maybe 3x other people now who've had similar experiences (after scouring the internet), and the only commonality I've found is ASD.

This is a bit of a pet project of mine, so if you want to chat about ASD shenanigans, please reach out to: asd.shenanigans@mailbox.org

Apologies if you've already discounted this, but serotonin syndrome came to mind when I read this.

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