Inevitable Wikipedia article about this:
https://en.wikipedia.org/wiki/Hypothetical_types_of_biochemi...
Inevitable Wikipedia article about this:
https://en.wikipedia.org/wiki/Hypothetical_types_of_biochemi...
The approach of "Smart people have thought of that, there are very few chemically useful alternatives" is the kind of thing that entrenches a person in their insistence that this is just a wide-scale failure of imagination. Witness their comment about "earthlike biology perspective". They want to believe a wider, weirder universe is possible. As a rule, it helps people feel heard to tell them they're right about something.
So yes. I'm going to present it as a staunch certainty that something else is possible but currently unknowable, invisible, and irrelevant. I'm doing this in the hopes that the message gets through that this is not simply parochialist arrogance at work, from which they might nobly dissent.
First order life, but what about second order?
If I make a complex 'mechano-computer' that can reproduce itself, how exactly is that different from life? Now it looks like the universe doesn't have any direct way to go to silicon based life, but indirection over carbon based life first seems very possible.