Using exFAT under macOS over a period of a few years led to several of my drives becoming corrupted. I have not had issues since I switched away from exFAT, and I am now convinced that macOS's exFAT driver is unacceptably terrible.

If you need a multiplatform filesystem for a thumb drive or small portable hard drive, I have had success with UDF. Surprisingly so, given that it's basically a hack. See: https://github.com/JElchison/format-udf. This basically won't work on drives over 2TB, however.