I understand the fundamental motivation for this sort of thing. The web is a static document display that over many decades of augmentation and extension has morphed into an app development platform. And arguably, a lot of the mechanics of it are less elegant than in purpose build app-development environments.

But, I don't think another language that tries to abstract the fundamentals is the solution to that. I think this is true for Hyperscript - as much as it is for JSX and Co. JavaScript is the most widely known programming language, has the most extensive knowledge base and the biggest ecosystem. And there's no shortage of frameworks that make using it easier without reinventing the wheel.

I believe using anything else for a serious project severely limits the talent pool from which you can hire, the ecosystem you can draw from and the maintainability of your project in the long run.