And the scale invariance of nature is clearly visible here. The cell is "small" compared to human scale but it is as complicated as any machine existing in human scale. There is no absolute small or big in nature.
And the "in silico" experiments are probably a bit of a sleeper for people outside the field. It is really obvious how improvements in computing power will have/had a transformative impact on this field. To go from poking out random molecules and growing dangerous things in a pitri dish to fast computer simulations from DNA seems like quite a big jump in how quickly the field can learn.
there's also an absolute big, known in cosmology, far beyond the scales of galaxies, galaxy clusters, etc... it's your mom
Also scale is subject to physical limitations. Bones can only carry that much weight - chemical processes are limited by - for example - maximum energy dissipation rate.