Paul Saladino says a lot of things. Which of his claims are you specifically referencing here?
About fat accumulation and decades of chronic inflammation in the brain being huge factors for Alzheimer's.
I couldn't find any example of him claiming anything related to fat accumulation in the brain. Could you link to an example or copy/paste a quote that you're referring to?
A broken clock is right two times a day.
A stopped clock is right twice a day. A broken clock could potentially never be right, like if it's perpetually 10 minutes behind.
That's not a broken clock, that's a clock that's set to the wrong time. Unless it remains 10 minutes behind, even when you set it 10 minutes forward, which would be a great prank gift.
A broken analogy never stops.
Paul Saladino has been saying that APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia?