>Software with 99.999999% uptime [0] may be the gold standard
No one seriously has that many nines as their "gold standard", because that's almost always too safe, which has costs:
>We strive to make a service reliable enough, but no more reliable than it needs to be. That is, when we set an availability target of 99.99%,we want to exceed it, but not by much: that would waste opportunities to add features to the system, clean up technical debt, or reduce its operational costs. In a sense, we view the availability target as both a minimum and a maximum. The key advantage of this framing is that it unlocks explicit, thoughtful risktaking.
https://sre.google/sre-book/embracing-risk/
see also: The optimal amount of fraud is non-zero https://www.bitsaboutmoney.com/archive/optimal-amount-of-fra...
In this case though, other commenters have pointed out plausible reasons for why the cohort studies can't be trusted. There's also lack of evidence for the casual mechanism behind the effect, so on the whole it seems fairly reasonable to demand better evidence.