I've had dogs all my life and live in a very tick-prone area. Nothing ever really worked, to be honest. It was a constant battle of attrition. I had to spray the house with nasty chemicals every few months cause that was pretty much the only thing that kind of tipped the balance against the ticks. I frankly don't know how we didn't get Lyme disease, we were exposed for decades.
Since these new meds appeared, ticks have completely disappeared from our property. They only provide 1-3 months of protection, but they're so effective at eradicating the parasite population that I've only had to use 3 pills in the past 4 years.