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The effort with mosquitos didn’t work. Forcing a gene with negative impact on survivability is touch

mosquitos are hard, but with ticks there are a few different vectors of attack.

My understanding is that ticks first need to bite a rodent that is infected to spread Lyme, so maybe gene editing on rodents?

Where has it actually been tried?

Google it. They released female mosquitos with a bad gene and they almost immediately got selected out.