Those pathological cases are really what inlining is for, with the exception of any tiny recursive functions that can't be tail call optimised.
There is also a significant number of projects that go to great lengths to force-override CFLAGS/CXXFLAGS (usually with «-O2 -g» or even with «-O») or make it extraordinary difficult to change the project's default CFLAGS, for no apparent reasons which eliminates a number of advanced optimisations in builds with default build settings.