My bet on the re-entry failure is that they have really poor attitude control. They definitely had some, but you can also see at different points that the plasma was shifting directions. At T+46, it was doing a spin as the first plasma started to show. At T+47, it was going down on the edge of the heat shields. At T+47:40 it appears to be going down engine first.
Moreover, I'm guessing the reason they skipped the mock re-entry burn was due to not being able to settle the propellant. Though it's really hard to tell if the turning of the Starship was to rotate which side was getting heating from the sun, or if it was spinning out of (or with less than desired) control.
Tim Todd noticed that the gas thrusters were icing over and then releasing the ice. So it's a reasonable guess that this was part of the issue, but that's leaning even more into speculation territory.