Another important caveat: many things we want to measure are not well-distributed to allow the CLT to hold. If it doesnt, the bulk of statistical methods don't work and the results are bunk.
Many quantities follow power-law distributions which would require trillions+ data points for the CLT to do its magic, ie., for the sample means of set A to be statistically-significantly different from set B would require 10^BIG if the property measured in A/B is powerlaw distributed.
Now, even worse: many areas of "science" study phenomena which is almost certainly power-law distributed, and use these methods to do so.