V8 and the new Mozilla engine are optimized to hell already. And they compile to native code. http://kailaspatil.blogspot.com/2011/08/jaegermonkey-archite... And they are efficient.. These engines have proven that you don't need pointers or explicit types to be an efficient Javascript implementation.
The only reason that I can see for these types of features like explicit types and pointers are to support systems programming, where they are required for certain activities (probably less that you would think though). For that, I would really love to see a CoffeeScript with those features available for use optionally. I think to do that you would want to find a way to compile directly to machine code or assembly or LLVM bytecode or something like that.