FDA Designates MM120 (LSD) Breakthrough Therapy for Generalized Anxiety Disorder
businesswire.com
businesswire.com
https://www.clinicaltrialsarena.com/news/mindmed-trial-anxie...
Still no study published, no information about blinding effectiveness. It does say that adverse events include hallucinations, which doesn't bode well for effective blinding.
So far there isn't really any strong evidence that hallucinogens including ketamine are more effective than placebo at relieving anxiety or depression (see for example the recent study showing no difference to placebo for ketamine under anaesthetic), even though we all strongly wish they were.
That's not counterevidence to ketamine's efficacy, it's evidence that the efficacy, if prior studies soundly demonstrated it, relies somehow on the user not being anesthetized during the treatment.
I don't think that surprises many advocates of psychodelic or hallucinogenic therapies.
And these are not the first class of treatments where blinding isn't practical. It does confound some forms of analysis when you can't acheive real blinding, but we've devised many alternative forms of analysis that we take as scientifically "good enough" to treat something as medicine.
Ketamine doesn't stop respiration. It causes profound dissociation and hallucinations, but I don't think it causes coma. It's definitely doing different things than GAs, at least.
So it doesn't seem unreasonable that ketamine wouldn't work if you're in a coma. I'd be surprised if LSD did either. Or anything, for that matter. There's not a lot metabolically happening in a neuron under coma.
Ketamine is an anaesthetic and has the same mechanism of action as inhalational anaesthetics. A trial of ketamine+anaesthetic vs placebo+anaesthetic might indicate that ketamine is no better than placebo, but equally it could indicate that general anaesthesia is an effective antidepressant. Your NMDA receptors don't particularly care whether they're being antagonised by ketamine, nitrous oxide or isoflurane.
Stock spike on Thru but not Dec (to <$10/share). The 6 mos trend might support what you're saying tho. Also, me ! a $ wonk.
ref:https://www.marketwatch.com/story/mindmeds-stock-jumps-24-af...
MDMA (ptsd), psilocybin (depression, anxiety), LSD
There are startups testing 2CB, DMT and some more exotic psychedelics for various indications as well.
And I would absolutely define it as "consciousness expanding" in the sense that having conversations with friends while under its influence opens up aspects of my emotional mind that are very difficult for me to uncover while sober.
At that dose, it causes a rapid release of neurotrophic factors, which restores the function of neuronal spines. Those spines are typically damaged by chronic exposure to stress. It may not necessarily be supported by a verbal insight into your emotional difficulties, although the brief period of neuroplasticity can lead to that.
There is usually complete relief from depressive symptoms within 24-48h, but it only lasts for as long as chronic exposure to stress doesn’t start again. In some patients this means that symptoms can return within a couple of weeks, unfortunately.
> MM120 is a tartrate salt form of lysergide, a semi-synthetic hallucinogen commonly known as LSD
I'd support decriminalization efforts instead: we let people with cancer get weed from a dispensary.
Why not let veterans and other people with a generalized anxiety disorder get LSD the same way?
For d-amphetamine making it a salt produces an effect similar to delayed release. The result is sold as a “more modern” ADHD treatment Vyvanse.
So is this achieving similar effect? Flattening the curve, so to speak?
Or maybe it’s just to distance itself from the recreational LSD culture?
And with LSD freebase that's not an unnecessary luxury, as it isn't the most stable against decomposition. To answer the question... probably this is the most stable formulation to get it into a pharmacy? I guess like you say, not blatantly calling it LSD helps image building too.
With vyvanse, that's actually something else: not a salt but an amino acid covalently bound to amphetamine. This gives a much stronger bond than between tartrate and lsd ions in the salt, one that can be hydrolysed slowly in the gut to produce the active drug. LSD tartrate doesn't have a similar slow release property.
Though, I am sure prescription drugs will always be legal with a prescription, assuming the prescription itself is legal. Even if this were counted as the Schedule I drug LSD that can't be prescribed, it'll probably get moved to Schedule II or III before any actual prescriptions are given out. So anyone who ever gets such a prescription in-hand will always be safe.
The salt is patentable.
Amazingly, I found a Swiss clinical trial from 2021 (!) comparing the pharmacokinetics of the freebase vs. tartarate in human subjects: https://classic.clinicaltrials.gov/ct2/show/NCT04865653
Switzerland is (free)based.
This is remarkable - IIRC previous studies (X) involved additional psychotherapy, and quite extensively.
(X) Huberman Labs. https://youtu.be/fcxjwA4C4Cw?feature=shared
(X) “how to change your mind” documentary (Netflix)
“Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities“, A. Szabo (2015).
https://doi.org/10.3389%2Ffimmu.2015.00358
Central nervous system inflammation does not feel good. There are many, many known links between mental or emotional ills and inflammation.
All the classical serotonin receptor 5-HT2A-activating psychedelics as well as MDMA are profoundly immunomodulatory. They reduce inflammation.
I'm neurodivergent, so it most definitely doesn't work this way for everyone, but it's extremely helpful for me and I hope that one day the law recognizes that.
If you're really concerned, just make sure your DNM vendor has consistently good user reviews.
I unironically trust random weirdos on Haight st and DNM vendors than the federal government.
While grandpa Joe's recent campaign speech was very inspiring, there's a very very long way to go before I can ever remotely trust the FDA again.
I say this as someone who's had high doses of LSD25 before and failed to hallucinate much if at all. I don't doubt that people can, but not everyone does.
(I support decriminalization, but I want safe regulated sources to be freely available. People shouldn't have to resort to the dark web or to random dealers on the street. People should have sources that are guaranteed safe, just like other supplements.)
Thanks, Doctor!