This is how I have my setup running, a moderately-outdated, but still beefy (E5-2699v4, 512GB ram, etc), Dell Precision tower, which originally started as a design machine with a handful of Autodesk and EDA tools. I wanted to try out proxmox, but I was too lazy to want to move all of those installed things off onto another host, reinstall, then move it back into a Windows VM. I suppose I could still run proxmox in a HyperV instance and then VMs within there, but it feels like too many layers of indirection.
HyperV is perfect for what I want to do, run a dozen or two sandbox and experimental VMs. I can pass through hardware, assign raw volumes, partition out network interfaces for routers and other shenanigans and it's stable too. And with RDP, I just use the mac version of the remote desktop client to use it interactively, which also works surprisingly well even over tailscale on another continent!