Individuals should "put in some mental groundwork" in preparation of taking any entheogen; my best advice would be to use a spirit guide / healer for your first trip, particularly if you're extremely anxious.

As example, I have previously been turned down [by a US MD] as "too anxious" to try legal ketamine-infusion therapy [immediately after loss of a parent].

In using a trained professional (e.g. see Oregon's new psilocybin guide certification) to help you determine your "use fitness," you can probably avoid a very bad experience...

Traditionally, and what the current research is showing, is that these substances are treatments for not being in a good place, mentally.