The Science Behind Ozempic Was Wrong

theatlantic.com

23 pointsturadg4 comments

The weight-loss effects of GLP-1 drugs have little to do with the gut.

https://web.archive.org/web/20240305193736/https://www.theat...

Wow this is a fascinating thesis -- GLP1 was known to affect the stomach AND the brain, and it certainly does affect the stomach, but for the weight loss properties to be simply brain-driven might be a bit simplistic.

It certainly does explain the effects on other kinds of addictive behavior, but that effect is less supported by research (that I can find, anyway).

There’s some pretty compelling research on the brain effects. Here’s a quick explainer: https://youtu.be/dCm6QLGnPPw?si=-OlxcXp8mRBHlCo7

In hindsight, this is somewhat obvious due to the anti addiction properties of GLP-1 agonists.

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