As soon as I saw the bit about many people with recurring CSF leaks also having connective tissue disorders, my heart sank. Sure enough, after reading a follow-up[0], it seems she has Ehlers-Danlos Syndrome. The experience I have of this is a bit off the beaten path: a kitten we adopted a few years ago ended up having the feline version of it... she was such a sweet, affectionate, energetic little girl, but we lost her to complications after only a year and seven months; she had very weak skin and slow healing, and the disease damaged her heart. (It's been a year and a half, and I still miss her dearly. She made a huge impact on my life in such a short time.)
EDS is uncommon in humans (and even less common in cats), and hits in varying levels of severity (there are a few different subtypes of the disease, caused by different genes). It affects the entire body, since there's connective tissue more or less everywhere, that depends on correct collagen packaging to function well. But it's rare enough that it's unlikely we'll find a cure, or even particularly effective treatment, for quite some time. I can't help but be impressed by people who manage to live full lives, while dealing with its effects for decades on end. I don't know if I'd be strong enough, in their position.