This ends up made worse if you’re using sync routes.
If you’re constrained on a resource such as a database connection pool, your framework will continue to pull http requests off the wire that a sane client will cancel and retry due to timeouts because it takes too long to get a connection out of the pool. Since there isn’t a straightforward way to cancel the execution of a route handler in every Python http framework I’ve seen exhibit this problem, the problem quickly snowballs.
This is an issue with fastapi, too- https://github.com/tiangolo/fastapi/issues/5759