You run an AI on that with a bunch of safeguards, and constant human albeit speed-of-light-delayed monitoring that can correct erroneous decision making.
(If we keep reasoning this way, humanity will forever be stuck on this ball of mud, eventually wiring our heads to computers, and then the closest we'll come to exploring the universe is browsing through pictures snapped by ancient probes.)
A. We retreat in the comfy matrix whilst we let robots rule the roost. If the matrix could simulate.. say.. Star Trek style exploration for you in a more interesting, comfortable and challenging way than reality, why would you want the watered down real version?
B. We digitize ourselves, but (most of us) prefer reality. To travel to a different world you get beamed over, into a vat-grown android body.
Human bodies are much too fragile for long distance space travel. Why add massive amounts of extra required resources (cryo-G couches, extra fuel due to those couches, bigger ship for those couches, redundancy, etc.) when you can just launch a robotic factory at much higher Gs, land (always perilous), let it bootstrap itself into a forward base, vat-grow a couple of android bodies and then you get to beam into the frontier :)
For the not-so-far future I see us putting a few bases on the moon and a very scrappy base on Mars, all manned by warm-blooded humans.