Our family have recently been in the situation where my partners 85 year old grandfather, who sometimes struggles to remember who we are, had to have his leg amputated due to some metalwork he had implanted in his knee 10 years ago having worn through his skin due to him losing muscle and being very thin from being bed bound. He has approximately zero chance of adapting to having his leg amputated and, in all honesty, most of the family hoped he would die on the operating table as he has no meaningful quality of life.