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VMware Workstation passthoughs are very reliable for me. I can't say the same for VirtualBox though.

My experience for generic Virtual Serial Port hardware

* MacOS Parallels - Abysmal performance, constant USB timeouts. Virtually useless

* Virtual box on Windows, emulating Windows - Able to detect device, but unable to talk to it.

* Virtual box on Linux emulating Windows - USB does not even detect.

I never had any problems with vbox usb passthru from lin.host to win.guest, so you might have a really specific case here, but I know there are loads of people running qemu on lin.host with all kinds of advanced hardware pass through configurations.

Thinking about it, if you have a very old motherboard the IOMMU layout might have hindered proper hardware separation.

But I doubt OP really need pass-through at all.

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