CrossOver is a WINE implementation for people that want a really nice and simple interface. I used to beta test apps for them ages ago, which was nice, as that got me a free copy of the pro product. They recently just cleaned house on that program, and I lost my access, which, you know, fair, but also it happened right as I was wanting to check them out again after having managed WINE with other tools on my workstation.

By default, it makes brand new prefixes, has profiles for well known apps to configure the prefixes accordingly, including managing downloading the installers.

Their fixes and changes to their version of WINE are almost always upstreamed, so eventually you do get those features in OSS WINE, but that's honestly never been the reason to get it. It's the much more friendly UX, and for those using WINE in business environments, a channel to get support for the framework.

For those that want better prefix management for their home projects, there are plenty of OSS projects doing that now. Whisky for macOS, and Bottles for Linux are two fine alternatives to help keep WINE prefix hygiene without it, but neither come with the "we can install this business app for you with no hassle" concierge features.

These folks do know WINE well though. There's a reason they're working with Valve on Proton, and why so many of the commits to WINE come from them.