> The team led by scientists at the Smurfit Institute of Genetics in Trinity’s School of Genetics and Microbiology and neurologists in the School of Medicine have also uncovered a novel form of MRI scan
A typical clinical MRI machine has a resolution of about 2mm. Small lesions are invisible to it. They are expensive to run and, more importantly, a scan takes a long time, so you usually only do some sort of specialized detail measurements, not a detailed "full picture" of everything. MRI machines typically run non-stop to be economically viable (just the helium coolant costs something like 200k$ per year), consequently your research likely competes with other teams', I presume. The contrasting agents able to cross the blood-brain-barrier are not substances without concern. They tend to accumulate in the brain, I guess people may be extra cautious with a hypothesis of hyperimmunity, or leaky blood vessels.
I am pretty sure a standard MRI scan of the brain did not show the described clinical evidence before.
Also:
> Undertaking this complicated clinical research study at a time of national crisis and when our hospital system was under severe pressure is a testament to the skill and resource of our medical trainees and staff.
> "The concept that many other viral infections that lead to post-viral syndromes might drive blood vessel leakage in the brain is potentially game changing and is under active investigation by the team.” — Matthew Campbell, Professor in Genetics and Head of Genetics at Trinity, and Principal Investigator at FutureNeuro.
The main issue is probably how little we know about the body in detail, really. Especially the immune system. And if your starting point is a diagnosis of "well, it's nothing else", that's a moving target, anyway. I guess, you could count a lot of basic research as CFS research.
Part of the article talks about how testing and confirmation of a COVID diagnosis was a requirement here, which helps narrow down the study.
Maybe most obvious things don’t get funded so the research cannot be done.