Or let's go back to ultra modern times. Nuclear warheads are shockingly small. Imagine telling something at the turn of the 20th century that soon a weapon the size of a small table would have a kill radius of multiple miles. I mean you can obviously imagine it, but it seems kind of silly to think about being actually real, until it turns out it is.
So there are two possibilities now. (1) Now we've finally reached that point, that we will only ever reach once, where our knowledge is advanced enough such that there will no longer any major revolutionary discoveries made. Or (2) we're just like every other generation throughout time who assumed that what they knew was, more or less, the peak of what's knowable (or at least not fundamentally wrong) only to have their own ignorance demonstrated with marked clarity in times yet to come.
Beyond the philosophical there are countless technical reasons to also think this is the case. Like you mention astronomy, yet so much of what's going on out there remains a complete mystery. Disharmony between the really big and really small aspects of the universe, whatever 'dark matter' and 'dark energy' truly are, the fact that observed galaxies are moving at rates far different than expected by relativity or Newtonian mechanics (including after factoring in whatever dark matter may be), that a big-bang would require a mysteriously convenient faster-than-light inflationary period to actually work, and countless other issues. So many things are breaking at scale, that it seems highly reasonable to assume that there remain yet many revolutionary and worldview-shifting discoveries to be made.