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In building this, I had to look this up for each rule. http://CSS3Please.com has the most compact 'reasoning' for each in the form of comments.

To answer your specific question, all browsers that support it do so without prefixes, but not all browser versions. For example, even with auto-updates, a non-negligible percentage of Chrome browsers out there are older.

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That's one of the many problems with the prefixes, we're stuck with them until we're sure that all the "modern" browsers' old versions are no longer in use. Thankfully for most of those it shouldn't take that long.

Chrome supports .box-shadow without prefixes 8 versions back according to http://caniuse.com/css-boxshadow. It looks like the most likely place to run into trouble is the previous versions of Safari and iOS Safari, as well as all versions of Android Browser (this one surprised me). Personally, I will continue to use it without prefixes unless it is really important that the shadows work for mobile devices.

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