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Comment by operatingthetan | Hacker News Reader

Amphetamines including Adderall are mildly neurotoxic, but that doesn't seem to bother those that take them.

Considering those with ADHD have a life-expectancy that's 13 years shorter than someone without it [1], I'll take whatever mild neurotoxicity you're pointing out in exchange for being less likely to get into a car accident or whatever else I have a tendency to do.

[1] - https://www.additudemag.com/adhd-life-expectancy-video/#:~:t....

That is not true. All studies have shown they are only neurotoxic if abused and by abused I mean taking nearly 10x of a normal dose. At that level Of abuse anything is neurotoxic.

>Adderall may have neurotoxic effects in doses higher than the recommended therapeutic dose; however, it may also potentially be neurotoxic in prolonged regular doses over a long period of time.

There is a lot of recent research on this and it does not agree with you.

https://www.sciencedirect.com/science/article/abs/pii/S00747...

I'd say it does agree with OP considering the article used "may" and is followed up by "Currently, there is not enough scientific evidence to support Adderall’s neurotoxicity. Additional research on the effects of prolonged stimulant use is necessary.

I believe OP was saying that neurotoxicity has only been definitively shown in higher doses. Granted I highly doubt no studies show neurotoxicity at lower doses, but it doesn't look to be a settled matter.

https://jpet.aspetjournals.org/content/315/1/91.long

>Amphetamine Treatment Similar to That Used in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder Damages Dopaminergic Nerve Endings in the Striatum of Adult Nonhuman Primates

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