Of course that if you've been conditioned for something that is no longer a choice.
If you have a broken leg and someone tells you to walk it off you're going to think they are clueless. If you literally have a [chemical] imbalance and someone tells you that you should be happy instead of being sad it's not as clear cut observing it, but it's also as infeasible as walking off a broken leg. Btw: being conditioned for something literally alters the chemical your brain/body releases.
As with the broken leg, you need help to figure out how to walk until it heals. Realizing that you need help and seeking and accepting the help is critical. Part of that help can be reframing how you view your interactions to transform what used to be implied and automatic to now being a choice.