I have 4 external all different sound cards and AMPs (USB), it's the same on all of them.
There is no software remedy, only re-connecting physically works (temporarily)
There is no software remedy, only re-connecting physically works (temporarily)
If they do, then the app in question will pass the audio raw to the external device without the OS or any existing mixers interfering at all.
Of course, no other audio will play - only that from the app with exclusive control. It's not perfect but it can help in these scenarios.