The perf impact of this or any hybrid design is also blunted by the power/cooling limits on non-hybrid designs: you can't afford to blast all the full-size cores on the chip at the max theoretical frequency at once anyway. Then, at the other end, lightly-threaded workloads can run mostly or only on the larger cores, so they're not heavily impacted either.
If there's a way this ends up fun for consumer folks that follow this stuff, it'd probably be by allowing products w/more cores. In server chips using Zen 4c (Bergamo), more cores is explicitly the focus. On their desktop platform, one CCD of full-sized cores and one of smaller cores would allow a 24C two-CCD package. That would add another "flavor" of CPU, the way X3D is another "flavor", but I suspect there are applications where the extra throughput could help. No particular hints that this is part of their plans, to be clear.