At least for us, we made the switch in preparation for the release of the M1 Mac machines.
It took about a year for things to simplify - originally we had to use qemu for dependencies and had to hack and compile a few other bits along the way. We have more gnarly deps than your average web app though.
Now the only thing we’re running on x86 is Sentry and I’ll stop self hosting that when I get a spare moment because it’s more of a beast to run than I like.