Every so often I price out RDS to replace our colocated SQL Server cluster and it's so unrealistically expensive that I just have to laugh. It's absurdly far beyond what I'd be willing to pay. The markup is enough to pay for the colocation rack, the AWS Direct Connects, the servers, the SAN, the SQL Server licenses, the maintenance contracts, and a full-time in-house DBA.
https://calculator.aws/#/estimate?id=48b0bab00fe90c5e6de68d0...
Total 12 months cost: 547,441.85 USD
Once you get past the point where the markup can pay for one or more full-time employees, I think you should consider doing that instead of blindly paying more and more to scale RDS up. You're REALLY paying for it with RDS. At least re-evaluate the choices you made as a fledgling startup once you reach the scale where you're paying AWS "full time engineer" amounts of money.