Looking through the docs, the main difference I see is that this is opting for a comparatively heavy-core approach which contrasts with Node's ruthless minimalism + third-party modules.
For example:
-file system access is convoluted with HTTP handling: req.response.sendFile()
-pieces of web framework functionality by default, but no full solution (RouteMatcher)
-integrated WebSockets with a novel but unconventional accept/reject API
-heavyweight SockJS integration
It will be interesting how all of his plays out. And I'm definitely interested in hearing evidence for claims such as
> a run-time with real concurrency and unrivalled performance