It very well can:
For example, let's assume you have a graphics editor running in the browser that stores files in the cloud. If it uses a vulnerable C library to decode image data, an attacker might be able to play havoc with your files despite the sandbox never technically having been breached.
This can be mitigated by either using a safe language, or having the decoder run in an isolated wasm instance. Either way, you have to design your application with these considerations in mind and can't just take arbitrary, potentially vulnerable applications, compile them to wasm and be done with it.