Some people hate interface builder and don't use it at all. I really like it and would have a really hard time getting rid of it. The amount of code you would need to write to make all of your views would be terrible.

I would liken it to not using HTML when you're making a web app and you can only use javascript to generate (by hand) all of the UI.

I quite like Interface Builder, and this sounds like a bit of a deal-breaker for me. I'd rather not have my controllers cluttered with UI-positioning code, etc. It's a much more elegant way to create you UI (most of the time).

I bet they are working on it, though...

I tried a bit, technically it works but currently you have to compile your xib to nib manually using ibtool.

That may have changed tough because I dropped the xib as I didn't really needed it.

In relation to working with Appcelerator or a similar system that allows you to load in images/views/visuals & position programmatically, I wouldn't say it's a problem, more a shift in practice.