No. To float you would need a gas lighter than hydrogen, which isnt a thing. And powered flight (wings) without oxygen would be trickey, requiring more of a rocket motor than an aeroplane engine.

Yes, you could use a balloon filled with vacuum, but lifting something the size of an orbital rocket in a hydrogren atmosphere would require a vacuum chamber at least the size of a city, possibly the size of a small state. It would probably be easier to build a tower.