Posting a secret key here and specifying "exactly one bit was flipped" reduces the problem to N guesses where N is the key length since you know all the other N - 1 bits are correct. Leaking just a few bits has catastrophic consequences, in your example all bits except one are leaked.
Is it possible to determine that this has happened though? If you're trying to recover an image and a bunch of bits are flipped, the result might be somewhat corrupted but a coherent image will still be visible. You know that the data was corrupted and where the damage is. Ciphers have avalanche effects, a single bit flip produces completely unusable output which by design reveals no information.
All that is to say, yes, this is a viable attack vector, even if some or many of the bits are flipped