We tried to hold out for as long as we could without an SUV. Ultimately, taking a week long trip with the family became focused around space management, having to play packing tetris and telling my wife "I don't think we have space for the pack and play". Sure we made it work, but it was stressful.
We got a 3 row SUV (3rd row collapses), and the additional space is just fantastic when it comes to packing. And when the cousins or grandparents are in town, the 3rd row comes in handy.