I've run musk based distro for a couple of years with no trouble (KISS Linux and now some hacked up Alpine monster I put together). I don't do streaming video that requires DRM -- which will be a non-starter due to the widevine/whatever plugins being compiled against glibc.
But yeah, full Wayland desktop (well, sway) and Firefox -- no problem. I occasionally use a debian chroot to pull up gnucash (accounting program) which works as a backup but it's rare. My debian chroot is mostly to run a 10 year old printer driver from Epson that's compiled against glibc, but doing a little trickery with a small C program works just fine with CUPS still running in alpine (print filters operate on stdin and stdout, so you can launch them in a chroot by themselves no problem).