If we take the highest reproducible frequency, two samples per wave, we find we could perfectly sample at the highest and lowest values of that wave, but we could have equally sampled the zero-crossing point, all depending on where in the phase the sample rate aligns with a given wave form. As the sampling has lost significant information, I believe a sample rate should be much higher than what Nyquist-Shannon would suggest for a high degree of reproducibility.
If your source is a digital signal, and you only need to reproduce that signal, of course 2x is ample.