Similarly, there's some papers w/ mice w/ knockout Parkinsonian genes getting parkinsonian features and lewy bodies when injected w/ abnormal misfolded synuclein from another mouse.
What exactly to do w/ this, no one is entirely sure yet.
Similarly, there's some papers w/ mice w/ knockout Parkinsonian genes getting parkinsonian features and lewy bodies when injected w/ abnormal misfolded synuclein from another mouse.
What exactly to do w/ this, no one is entirely sure yet.
Actually it may seem so [1], though still there is not any conclusive evidence to support a transmission hypothesis really as all this could be due to increased stress and such factors. Also, brain surgeons' increased risk of AD and more reports of associated risks with regard to contamination from brain operations [2] (similar to the article's ones) provide more indications that such a hypothesis is not completely implausible. Though also far from strongly supporting it or anything, as there is no proper experiment design with control groups etc to make better conclusions.
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945313/ [2] https://www.medicaldesignandoutsourcing.com/report-suggests-...
Sounds like a sensible next step would be to try and replicate this in animal models (i.e. treat animals with growth hormones extracted from cadavers of same species) to identify the proteins/prions that trigger the pathogenesis of Alzheimer's, which could perhaps be drug targets for at least a subset of AD causes.
Columbia trial paper: https://www.nejm.org/doi/full/10.1056/nejm200103083441002
Tampa trial paper: https://pubmed.ncbi.nlm.nih.gov/12953276/
Additionally, it looks like I totally missed at least one European program at Lund University (review paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345652/)
I've heard rumblings re preclinical prep work w/ the Takashi group at Kyoto University as well, not sure where that's at at the moment.
I randomly found this review, but haven't had a chance to plough thru it yet, but I wouldn't be surprised that the stem cell tech these days makes whatever they used 20 years ago ancient and crude by comparison https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890289/
https://pubmed.ncbi.nlm.nih.gov/18391962/
edit: competing group also managed to publish theirs at the same time
Is this a special kind of mouse?
w/o = without
This comment is full of abbreviations (PD = Parkinson's Disease, AD = Alzheimer's Disease) that makes it a bit difficult to read (if you don't know / realize what those abbreviations stand for)