> someone who is already very sick
But what caused this initial sickness?
https://www.epa.gov/sciencematters/links-between-air-polluti...
: In a study funded in part by EPA, researchers from Johns Hopkins University found that children exposed to outdoor coarse particulate matter (PM10-2.5), were more likely to develop asthma
: Coarse PM can come from roadway particles such as brake and tire wear, and mixtures of road dust and metals.
: This finding is significant because while researchers have generally found that exposure to fine particulate matter (PM2.5) is associated with the development of asthma and other respiratory and cardiovascular diseases.
: While researchers do not fully understand how air pollution exposure increases asthma prevalence, evidence suggests air pollutants suppress genes that regulate the immune system’s ability to differentiate an allergen from a dangerous foreign substance, such as a virus or bacteria. The immune system then goes into action, setting up an inflammatory response whether the substance is harmful or not, which leads to asthma.
: In the study, researchers from the Children’s Center at Stanford University examined the impact of air pollution on two genes involved in immune tolerance in children from an area known to have high air pollution levels. Researchers found that short-term and long-term exposures to high levels of carbon monoxide, nitrogen dioxide, and PM 2.5 were associated with alterations to these two genes and those alterations were significantly associated with asthma.