I don't see it happening any time soon, but I'd love to see PDF be replaced as the end-all-be-all standard for academic publishing, technical manuals, corporate (non-public) documentation etc.
Every time I open a PDF of an academic paper on my phone on the subway and find myself furiously side-scrolling, I keep wondering if having performant mobile PDF renderers and high-DPI displays was maybe a blessing in disguise:
It's a bit better than not being able to read these types of documents on the go at all, but really not by much.