How can one guarantee once tightened bolts remain tight forever?
There are plenty of ways to ensure bolts stay tight that work, and these plug doors have been in service on other planes for a long time with no issues.
The entire rotor assembly (literally what holds it up) on some helicopters is held on by a single nut, for example. [https://en.m.wikipedia.org/wiki/Jesus_nut]
This doesn’t appear to be a case of the engineers not designing it safely - but it not being installed correctly and no one catching it before it rolled out the door.
Safety wiring: https://en.wikipedia.org/wiki/Safety_wire
This is actually required for some bolts per aviation regulations. I safety wired nearly every suspension/chassis bolt on my race car when I built it.